Baritussio A, Clements J A
Respir Physiol. 1981 Sep;45(3):323-31. doi: 10.1016/0034-5687(81)90015-3.
Electron microscopic evidence has shown that the occlusion of one pulmonary artery acutely decreases the content of lamellar inclusion bodies in alveolar type II cells. We studied the effect of unilateral pulmonary artery occlusion (UPAO) on the estimated alveolar pool of saturated phosphatidylcholine (SPC). Under pentobarbital anesthesia 13 rabbits, spontaneously breathing, underwent UPAO for 1--7 hours by balloon catheter. Eight rabbits with balloon deflated in the pulmonary trunk served as controls. After sacrifice the lungs were excised and alveolar SPC was harvested by lavage. After UPAO the alveolar pool of SPC was significantly higher in the occluded lungs than in the unoccluded ones. The average difference was 33.7% after 1 hour and 14.5% after 2 hours. After 4 and 7 hours of occlusion the alveolar pools of SPC in occluded and unoccluded lungs were not significantly different. We suggest that the temporarily larger pool size in the occluded lungs was due to an increase in surfactant secretion, although we cannot rule out entirely a decrease in the rate of clearance.
电子显微镜证据表明，急性阻塞一条肺动脉会降低II型肺泡细胞中板层小体的含量。我们研究了单侧肺动脉阻塞（UPAO）对饱和磷脂酰胆碱（SPC）估计肺泡池的影响。在戊巴比妥麻醉下，13只自主呼吸的兔子通过球囊导管接受UPAO 1至7小时。8只在肺动脉干中球囊未充盈的兔子作为对照。处死后切除肺脏，通过灌洗收集肺泡SPC。UPAO后，阻塞肺中SPC的肺泡池明显高于未阻塞肺。1小时后平均差异为33.7%，2小时后为14.5%。阻塞4小时和7小时后，阻塞肺和未阻塞肺中SPC的肺泡池无显著差异。我们认为，阻塞肺中暂时较大的池大小是由于表面活性剂分泌增加所致，尽管我们不能完全排除清除率降低的可能性。
