Cassio D, Weiss M C, Ott M O, Sala-Trepat J M, Friès J, Erdos T
Cell. 1981 Dec;27(2 Pt 1):351-8. doi: 10.1016/0092-8674(81)90418-9.
Rat hepatoma clones whose cells do and do not produce albumin, as well as somatic hybrid between the two types of cells, have been examined for albumin mRNA. A direct proportionality between the rate of albumin production and the concentration of albumin mRNA sequences was found for all albumin-producing hepatoma and hybrid clones, indicating that rate of synthesis of the protein is determined by the concentration of its mRNA. Albumin-negative dedifferentiated variant and somatic hybrid cells contain fewer than one to five molecules of albumin mRNA per cell; the block in expression of the gene appears to be at the same (probably transcriptional) level in variants and their somatic hybrids.
对能产生白蛋白和不能产生白蛋白的大鼠肝癌克隆，以及这两种细胞之间的体细胞杂种进行了白蛋白信使核糖核酸（mRNA）检测。在所有产生白蛋白的肝癌和杂种克隆中，发现白蛋白产生速率与白蛋白mRNA序列浓度之间存在直接比例关系，这表明该蛋白质的合成速率由其mRNA的浓度决定。白蛋白阴性的去分化变体和体细胞杂种细胞每个细胞含有的白蛋白mRNA分子少于一至五个；在变体及其体细胞杂种中，该基因表达的阻断似乎处于相同（可能是转录）水平。
