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循环糖皮质激素耗竭对大鼠肝脏多聚核糖体多聚腺苷酸化RNA的影响。

Changes induced in rat liver polysomal polyadenylated RNAs by depletion of circulating glucocorticoids.

作者信息

Bajwa W, Birnie G D, Knowler J T

出版信息

Nucleic Acids Res. 1982 Jun 11;10(11):3541-60. doi: 10.1093/nar/10.11.3541.

DOI:10.1093/nar/10.11.3541
PMID:6179044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320730/
Abstract

The effects of adrenalectomy on the complexity and the relative abundances of rat liver polyadenylated mRNAs have been investigated. The qualitative and quantitative changes induced by adrenalectomy have been measured by hybridisation of polysomal polyadenylated RNAs from the livers of normal and adrenalectomised rats with total cDNAs, fractionated cDNAs, cDNA representing RNAs specific to normal liver, total unique-sequence DNA and unique-sequence DNA complementary to normal liver polysomal RNA. These analyses indicated that, by 14 days after adrenalectomy, the equivalent of about 7000 sequences of average length 2000 nucleotides can no longer be detected in liver polysomes. Many other sequences are decreased in abundance as compared to normal liver, but some abundant sequences become more abundant. Administration of a glucocorticoid hormone (dexamethasone) very rapidly reverses these changes.

摘要

已研究了肾上腺切除术对大鼠肝脏多聚腺苷酸化mRNA的复杂性和相对丰度的影响。通过将正常大鼠和肾上腺切除大鼠肝脏的多聚体多聚腺苷酸化RNA与总cDNA、分级分离的cDNA、代表正常肝脏特异性RNA的cDNA、总单拷贝序列DNA以及与正常肝脏多聚体RNA互补的单拷贝序列DNA杂交，来测定肾上腺切除术引起的定性和定量变化。这些分析表明，肾上腺切除术后14天，肝脏多聚体中再也检测不到相当于约7000个平均长度为2000个核苷酸的序列。与正常肝脏相比，许多其他序列的丰度降低，但一些丰富序列变得更加丰富。给予糖皮质激素（地塞米松）能非常迅速地逆转这些变化。

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Changes induced in rat liver polysomal polyadenylated RNAs by depletion of circulating glucocorticoids.循环糖皮质激素耗竭对大鼠肝脏多聚核糖体多聚腺苷酸化RNA的影响。
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本文引用的文献

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Studies on the mechanism of regulation by cortisone of the metabolism of liver purine and ribonucleic acid.可的松对肝脏嘌呤和核糖核酸代谢调节机制的研究。
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Biochem J. 1982 Feb 15;202(2):491-7. doi: 10.1042/bj2020491.
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Gene expression in eukaryotes.真核生物中的基因表达。
Science. 1981 Feb 13;211(4483):667-74. doi: 10.1126/science.6256857.
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Deoxyribonuclease I sensitivity of the nontranscribed sequences flanking the 5' and 3' ends of the ovomucoid gene and the ovalbumin and its related X and Y genes in hen oviduct nuclei.鸡输卵管细胞核中卵类粘蛋白基因以及卵清蛋白及其相关的X和Y基因5'端和3'端侧翼非转录序列的脱氧核糖核酸酶I敏感性。
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