1α,25-二羟基维生素D3，一种促进骨修复的维生素D代谢产物。

Brumbaugh P F, Speer D P, Pitt M J

Am J Pathol. 1982 Feb;106(2):171-9.

1 alpha, 25-dihydroxyvitamin D3, the hormonal form of vitamin D3 that mediates calcium translocation in intestine and bone, was tested for its ability to promote fracture repair. Chicks were raised on a vitamin D-deficient diet supplemented with 1 alpha, 25-dihydroxyvitamin D3 for 3 weeks. Following fracture of the humerus, those chicks that did not receive continued 1 alpha, 25-dihydroxyvitamin D3 supplementation showed prolonged fracture healing, abnormal enchondral bone formation delayed remodeling of woven bone and osseous union, but normal formation of callus. Fracture repair in chicks receiving 1 alpha, 25-dihydroxyvitamin D3 was normal. These data indicate that 1 alpha, 25-dihydroxyvitamin D3 promotes bone repair in the absence of vitamin D3, 25-hydroxyvitamin D3, and 24,25-dihydroxyvitamin D3.

1α,25 - 二羟维生素D3是维生素D3的激素形式，可介导肠道和骨骼中的钙转运，对其促进骨折修复的能力进行了测试。将雏鸡饲养在缺乏维生素D的饮食中，并补充1α,25 - 二羟维生素D3，持续3周。肱骨骨折后，那些未继续补充1α,25 - 二羟维生素D3的雏鸡骨折愈合时间延长，软骨内骨形成异常，编织骨重塑延迟，骨结合延迟，但骨痂形成正常。接受1α,25 - 二羟维生素D3的雏鸡骨折修复正常。这些数据表明，在缺乏维生素D3、25 - 羟维生素D3和24,25 - 二羟维生素D3的情况下，1α,25 - 二羟维生素D3可促进骨修复。