Briones-Urbina R, Bear J C, Farid N R
Tissue Antigens. 1982 Jan;19(1):20-4. doi: 10.1111/j.1399-0039.1982.tb01412.x.
Serum levels of immunoglobulins (Ig) IgA, IgG and IgM were measured in 96 HLA-typed patients with Graves' disease and an equal number of sex and age matched controls. Patients showed significantly increased serum immunoglobulin levels compared to controls. HLA DR3-positive patients had larger elevations of IgG concentration than their HLA-DR3-negative counterparts. Variation in serum immunoglobulin levels was not associated with sex, treatment or ophthalmopathy. It is suggested that the hypergammaglobulinemia of Graves' disease is related to defective suppressor cells triggered by Ig or Ig-linked genes. HLA-related gene(s) must, in addition, be involved to account for hypergammaglobulinemia G in the HLA DR3-positive subset of patients.
对96例已进行HLA分型的格雷夫斯病患者以及同等数量性别和年龄匹配的对照者测定了血清免疫球蛋白（Ig）IgA、IgG和IgM水平。与对照组相比，患者血清免疫球蛋白水平显著升高。HLA DR3阳性患者的IgG浓度升高幅度大于HLA-DR3阴性的患者。血清免疫球蛋白水平的变化与性别、治疗或眼病无关。提示格雷夫斯病的高球蛋白血症与由Ig或Ig连锁基因触发的抑制细胞缺陷有关。此外，HLA相关基因必定参与其中，以解释患者HLA DR3阳性亚组中的高球蛋白血症G。
