Mañas-Almendros M, Ross R, Care A D
Q J Exp Physiol. 1982 Apr;67(2):269-80. doi: 10.1113/expphysiol.1982.sp002635.
The relationship between the concentration of phosphate in plasma and parotid saliva was studied in six conscious sheep and a goat, either intact or thyroparathyroidectomized (t.x.p.t.x.), under conditions designed to minimize marked fluctuations in flow rate of saliva. A linear relationship between acutely induced changes in plasma phosphate concentration and the phosphate level in saliva has been demonstrated in both intact and t.x.p.t.x. animals. Dietary phosphorus depletion caused adaptation of salivary phosphate concentration so that less was secreted at a given concentration of plasma phosphate. Attention is drawn to the similarity between this phenomenon and that already described for the proximal renal tubule. Parathyroid hormone (PTH) was shown to reduce the salivary phosphate concentration with little or no effect on phosphataemia. The administration of 1,25-dihydroxycholecalciferol (1,25(OH)2CC) also caused a reduction in salivary phosphate concentration despite hyperphosphataemia and hypercalcaemia. It is suggested that salivary phosphate concentration can be influenced directly by the concurrent level of plasma phosphate but that this relationship can be modified by the circulating concentration of 1,25(OH)2CC and indirectly by PTH via increased production of 1,25(OH)2CC.
在六只清醒的绵羊和一只山羊身上，研究了血浆中磷酸盐浓度与腮腺唾液之间的关系。这些动物要么完整，要么进行了甲状腺甲状旁腺切除术（t.x.p.t.x.），实验条件旨在尽量减少唾液流速的显著波动。在完整动物和t.x.p.t.x.动物中，均已证明血浆磷酸盐浓度的急性诱导变化与唾液中的磷酸盐水平之间存在线性关系。饮食中磷的缺乏导致唾液磷酸盐浓度适应性变化，因此在给定的血浆磷酸盐浓度下分泌减少。请注意这一现象与近端肾小管中已描述的现象之间的相似性。甲状旁腺激素（PTH）被证明可降低唾液磷酸盐浓度，而对血磷水平影响很小或没有影响。尽管存在高磷血症和高钙血症，给予1,25 - 二羟胆钙化醇（1,25(OH)2CC）也会导致唾液磷酸盐浓度降低。研究表明，唾液磷酸盐浓度可直接受血浆磷酸盐同时水平的影响，但这种关系可被1,25(OH)2CC的循环浓度改变，并且甲状旁腺激素可通过增加1,25(OH)2CC的产生间接影响。
