Wright R D, Blair-West J R, Nelson J F, Tregear G W
J Endocrinol. 1982 Jul;94(1):37-41. doi: 10.1677/joe.0.0940037.
Administration of bovine parathyroid hormone (PTH) preparations increased the phosphate concentration in the parotid saliva of sheep. Data on the site of action of PTH (1-84) were obtained by (a) equimolar infusions of PTH (1-84) and (1-34) directly into the arterial blood supply of the vascularly isolated parotid gland in anaesthetized sheep, (b) intravenous infusion of PTH (1-84) at a similar rate and (c) intra-arterial infusion of PTH (1-84) with complete drainage of the venous effluent from the gland during the infusion. Results showed substantial time- and dose-response identity of the two peptides, at 10(-9) to 4 X 10(-9) mol/l in arterial blood, in raising salivary phosphate concentration. The effect of PTH (1-84) was not due to recirculated fragments because the response was obtained when recirculation was prevented by complete venous drainage and little or no response occurred when the same infusion was given i.v.
给予牛甲状旁腺激素（PTH）制剂可提高绵羊腮腺唾液中的磷酸盐浓度。通过以下方式获得了关于PTH（1-84）作用部位的数据：（a）将PTH（1-84）和（1-34）等摩尔直接输注到麻醉绵羊的血管分离腮腺的动脉血供中；（b）以相似速率静脉输注PTH（1-84）；（c）在输注过程中动脉内输注PTH（1-84）并完全引流腺体的静脉流出物。结果表明，在动脉血中浓度为10^(-9)至4×10^(-9)mol/L时，这两种肽在提高唾液磷酸盐浓度方面具有显著的时间和剂量反应一致性。PTH（1-84）的作用并非由于再循环片段，因为当通过完全静脉引流防止再循环时可获得反应，而静脉内给予相同输注时几乎没有反应。
