来自佛罗里达赤潮海洋甲藻短裸甲藻的两种毒素的毒性

Toxicity of two toxins from the Florida red tide marine dinoflagellate, Ptychodiscus brevis.

作者信息

Baden D G, Mende T J

出版信息

Toxicon. 1982;20(2):457-61. doi: 10.1016/0041-0101(82)90009-5.

Abstract

The purification and crystallization of T17, a toxin from Ptychodiscus brevis, is reported. The toxicity of this compound and a second toxin known as T34 are compared by i.v., i.p. and oral administration in mice. Both toxins produce symptoms characteristic of muscarnic stimulants; hypersalivation, rhinorrhea and excessive urination and defecation being the most commonly observed. T17, which is orally toxic, is believed to be the agent responsible for Neurotoxic Shellfish Poisoning.

摘要

据报道，短裸甲藻毒素T17已被提纯并结晶。通过对小鼠静脉注射、腹腔注射和口服给药，比较了该化合物与另一种名为T34的毒素的毒性。两种毒素均产生毒蕈碱兴奋剂的典型症状；流涎过多、鼻溢以及排尿和排便过多是最常见的症状。口服有毒的T17被认为是导致神经性贝类中毒的介质。