Nijkamp F P, Sitsen J M
Pharm Weekbl Sci. 1982 Dec 17;4(6):165-71. doi: 10.1007/BF01959134.
Immunological and non-immunological injury induce as a result of the action of the enzyme lipoxygenase the release of a series of arachidonic acid metabolites known as leukotrienes. The leukotrienes play an important role in allergic and inflammatory disease. Leukotrienes C4, D4 and E4 which recently have been recognized as constituents of the allergic mediator slow reacting substance of anaphylaxis (SRS-A) induce powerful bronchoconstriction, plasma exudation and weal and flare responses. Leukotriene B4 is involved in the regulation of chemotaxis, chemokinesis and other aspects of both cellular and vascular inflammation. The development of specific lipoxygenase inhibitors may lead to a new class of drugs for the treatment of bronchial asthma and chronic inflammatory diseases.
免疫性和非免疫性损伤是由于脂氧合酶的作用，诱导一系列被称为白三烯的花生四烯酸代谢产物的释放。白三烯在过敏性和炎性疾病中起重要作用。白三烯C4、D4和E4最近已被确认为过敏介质过敏反应慢反应物质（SRS-A）的成分，可诱导强烈的支气管收缩、血浆渗出以及风团和潮红反应。白三烯B4参与趋化性、趋化运动以及细胞和血管炎症其他方面的调节。特异性脂氧合酶抑制剂的开发可能会带来一类用于治疗支气管哮喘和慢性炎性疾病的新型药物。
