Woods J R, Coppes V, Brooks D E, Freeman M, Knowles P J, Parisi V, O'Mara P, McCarty G E
Am J Obstet Gynecol. 1982 Aug 15;143(8):944-51. doi: 10.1016/0002-9378(82)90479-3.
Visual evoked potentials were measured in eight exteriorized near-term fetal lambs prior to and during 8 minutes of asphyxia and during 1 hour of newborn survival. Four of the lambs were then extubated, and measurements were continued while the lambs were observed for behavior and gross motor function. Early in the asphyctic period, marked changes in the visual evoked potential occurred in association with a fall in Po2, whereas during the postexposure period the visual evoked potential appeared to recover independently of cardiovascular or arterial blood gas values. Moreover, early wave components of the visual evoked potentials were more resistant to asphyxia than were later components and responded more quickly to resuscitative efforts. During the survival period the visual evoked potential did not correlate with gross motor function when animals were exposed to moderate acidosis. After severe acidosis abnormal visual evoked potentials were seen during periods of clinical deterioration.
在八只近足月的体外胎儿羔羊中，测量了窒息8分钟之前、期间以及新生儿存活1小时期间的视觉诱发电位。然后对其中四只羔羊进行拔管，并在观察羔羊行为和总体运动功能的同时继续进行测量。在窒息期早期，视觉诱发电位出现明显变化，同时伴有血氧分压下降，而在暴露后阶段，视觉诱发电位似乎独立于心血管或动脉血气值而恢复。此外，视觉诱发电位的早期波成分比后期成分对窒息更具抵抗力，并且对复苏努力的反应更快。在存活期，当动物处于中度酸中毒时，视觉诱发电位与总体运动功能无关。严重酸中毒后，在临床恶化期间可见异常视觉诱发电位。
