Greer F R, Tsang R C, Searcy J E, Levin R S, Steichen J J
Am J Clin Nutr. 1982 Sep;36(3):431-7. doi: 10.1093/ajcn/36.3.431.
During lactation maternal losses of calcium and phosphorus through human milk average 220 to 340 and 110 to 170 mg/day, respectively. The present study reports maternal serum concentrations of vitamin D metabolites, parathyroid hormone, calcitonin, calcium, magnesium, and phosphorus during the first 6 months of lactation. Serum calcium and magnesium concentrations increased during the first 6 months of lactation. Serum 1,25-(OH)2 vitamin D was increased at 6 months of lactation compared to values in nonpregnant nonlactating controls. During this same period, serum parathyroid hormone decreased slightly and serum calcitonin remained unchanged. Our data do not support the observation that lactation represents a state of physiological hyperparathyroidism. On the contrary, our results suggest that lactating women are able to adequately compensate for the losses of calcium and phosphorus during the early months of lactation, although increased serum 1,25-(OH)2 vitamin D concentrations may be necessary to maintain calcium homeostasis with lactation beyond 6 months.
哺乳期母亲通过母乳流失的钙和磷平均分别为每天220至340毫克和110至170毫克。本研究报告了哺乳期前6个月母亲血清中维生素D代谢产物、甲状旁腺激素、降钙素、钙、镁和磷的浓度。哺乳期前6个月血清钙和镁浓度升高。与非孕非哺乳期对照组相比，哺乳期6个月时血清1,25-(OH)2维生素D升高。在同一时期，血清甲状旁腺激素略有下降，血清降钙素保持不变。我们的数据不支持哺乳期代表生理性甲状旁腺功能亢进状态的观点。相反，我们的结果表明，哺乳期妇女在哺乳的最初几个月能够充分补偿钙和磷的流失，尽管可能需要增加血清1,25-(OH)2维生素D浓度以维持超过6个月哺乳期的钙稳态。
