砷酸钠对哺乳动物细胞体外细胞遗传学效应的研究。
Studies of cytogenetic effects of sodium arsenicals on mammalian cells in vitro.
作者信息
Wan B, Christian R T, Soukup S W
出版信息
Environ Mutagen. 1982;4(4):493-8. doi: 10.1002/em.2860040408.
PMID:6896854
Abstract
The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary (CHO) cells is reported. Chromosome aberrations were induced with both arsenic compounds. Trivalent arsenic was more clastogenic than pentavalent arsenic. Sodium arsenite was also shown to produce increased sister chromatid exchange in CHO cells and increased chromosome breakage in human lymphocytes.
摘要
报道了亚砷酸钠和砷酸钠对中国仓鼠卵巢（CHO）细胞的细胞毒性和细胞遗传学效应。两种砷化合物均能诱导染色体畸变。三价砷比五价砷更具断裂染色体的作用。亚砷酸钠还被证明可使CHO细胞中的姐妹染色单体交换增加，并使人类淋巴细胞中的染色体断裂增加。
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