Lux M, Eckert H, Magdon E
Z Erkr Atmungsorgane. 1982;158(3):277-84.
The morphological changes on lungs of thorax irradiated mice, receiving a single dose of fast neutron and 60 cobalt radiation were investigated. Lungs were studied by histological and histochemical methods 2 weeks up to 10 months. Harvest changes were found after a time of 4-8 weeks. With histochemical methods more detailed damages are seen in contrast to routine histology. Two weeks post irradiation disturbances of phospholipid synthesis in alveolar epithelium cells of type II (AEC II) are found. Impairment of capillary endothelial cells are indicated by decreased activity of adenosine triphosphatase. Increased activity of beta-glucuronidase is seen in damaged bronchial epithelium.
研究了接受单次快中子和钴-60辐射的胸部照射小鼠肺部的形态学变化。采用组织学和组织化学方法对肺部进行了为期2周直至10个月的研究。在4-8周后发现了收获期变化。与常规组织学相比，组织化学方法能观察到更详细的损伤。照射后两周，发现II型肺泡上皮细胞（AEC II）的磷脂合成受到干扰。腺苷三磷酸酶活性降低表明毛细血管内皮细胞受损。在受损的支气管上皮中可见β-葡萄糖醛酸酶活性增加。
