Crowell W T, Grizzle W E, Siegel A L
Arch Pathol Lab Med. 1982 Nov;106(12):599-603.
To our knowledge, this study is the first to correlate the results of biochemical, electron microscopic (EM), and histochemical analyses of tissues from functional paragangliomas of the upper carotid area with a patient's clinical symptoms. The tumor tissues from our two patients contained epinephrine, norepinephrine, and dopamine. Neurosecretory granules were identified in both tumors by EM and by the Grimelius silver stain. The patient with the most severe symptoms exhibited evidence of higher circulating levels of catecholamines by biochemical, EM, and histochemical analyses.
据我们所知，本研究首次将来自颈上部区域功能性副神经节瘤组织的生化、电子显微镜（EM）和组织化学分析结果与患者的临床症状相关联。我们两名患者的肿瘤组织中含有肾上腺素、去甲肾上腺素和多巴胺。通过EM和Grimelius银染色在两个肿瘤中均鉴定出神经分泌颗粒。通过生化、EM和组织化学分析，症状最严重的患者表现出循环儿茶酚胺水平较高的证据。
