Nikolai T F, Coombs G J, McKenzie A K, Miller R W, Weir G J
Arch Intern Med. 1982 Dec;142(13):2281-3. doi: 10.1001/archinte.142.13.2281.
The duration of the hyperthyroidism associated with lymphocytic thyroiditis (LT) with spontaneously resolving hyperthyroidism (SRH) was serially monitored in groups of patients who were not given any treatment (control subjects) or treated with propylthiouracil and/or propranolol hydrochloride and prednisone. The length of time for the thyroxine tests from diagnosis to the normal range was 57 +/- 17, 45 +/- 13, and 15 +/- 7 days (mean +/- SD) indicating a dramatic response to prednisone therapy but none to propylthiouracil and/or propranolol therapy. Five patients were found who had seven episodes of SRH while receiving thyroid hormone suppression therapy after having verified chronic LT (two patients) and LT-SRH (three patients). This indicates that thyroid suppression with thyroid hormone may be ineffective in preventing this disease. Two patients were treated by subtotal thyroidectomy because of recurrent or prolonged episodes of SRH. From this experience, the therapeutic alternatives available to the clinician are reviewed.
对未接受任何治疗的患者组（对照组）以及接受丙硫氧嘧啶和/或盐酸普萘洛尔及泼尼松治疗的患者组，连续监测了与淋巴细胞性甲状腺炎（LT）相关的甲状腺功能亢进伴自发缓解性甲状腺功能亢进（SRH）的持续时间。从诊断到甲状腺素检测结果恢复正常范围的时间分别为57±17天、45±13天和15±7天（平均值±标准差），这表明泼尼松治疗有显著效果，而丙硫氧嘧啶和/或普萘洛尔治疗无效。在确诊为慢性LT（2例患者）和LT-SRH（3例患者）后接受甲状腺激素抑制治疗期间，发现5例患者出现了7次SRH发作。这表明甲状腺激素抑制甲状腺功能在预防这种疾病方面可能无效。2例患者因SRH复发或持续发作接受了甲状腺次全切除术。基于这一经验，对临床医生可用的治疗选择进行了综述。
