致死剂量的内毒素破坏肠上皮细胞之间的通透性屏障（紧密连接）。
Disruption of the permeability barrier (zonula occludens) between intestinal epithelial cells by lethal doses of endotoxin.
作者信息
Walker R I, Porvaznik M J
出版信息
Infect Immun. 1978 Aug;21(2):655-8. doi: 10.1128/iai.21.2.655-658.1978.
Abstract
A freeze-fracture technique was used to examine the most apical intercellular junctional complex between intestinal epithelial cells (the tight or occluding junction) in mice after challenge with endotoxin. Some of these junctions were disrupted after challenge and may be a site for leakage of microbial agents from the lumen.
摘要
采用冷冻断裂技术检查内毒素攻击后小鼠肠道上皮细胞间最顶端的细胞间连接复合体（紧密连接或封闭连接）。攻击后部分此类连接被破坏，可能是微生物因子从肠腔渗漏的部位。
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