Andrieu J M, Ochoa-Molina M E
Nouv Presse Med. 1982 Dec 4;11(49):3623-5.
The influence of MOPP therapy on pregnancy and offspring was retrospectively studied by means of a questionnaire in 68 women who had been given 3 to 6 cycles of the drug combination for Hodgkin's disease between 1972 and 1976. All were aged from 16 to 45 years at the time of diagnosis; none had received abdominal irradiation. Before treatment, 72 pregnancies had occurred in 36 women; 31 children were born and 2 of these had minor congenital abnormalities. After treatment, 30 pregnancies were recorded in 22 of the 50 women who were still menstruating; 22 children were born, and only one had a minor congenital malformation; all children showed normal psychomotor development. It is concluded that MOPP does not seem to have any effect on fertility, pregnancy and offspring of those women (73,6%) who continue having menstruations after treatment.
通过问卷调查的方式，对1972年至1976年间因霍奇金病接受3至6个周期MOPP联合化疗的68名女性的妊娠及子代情况进行了回顾性研究。所有患者诊断时年龄在16至45岁之间；均未接受过腹部放疗。治疗前，36名女性中有72次妊娠；31名儿童出生，其中2名有轻微先天性异常。治疗后，仍有月经的50名女性中有22名记录到30次妊娠；22名儿童出生，只有1名有轻微先天性畸形；所有儿童的精神运动发育均正常。结论是，MOPP似乎对治疗后仍有月经的女性（73.6%）的生育力、妊娠及子代没有任何影响。
