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通过测量血清水平进行剂量监测——临床药理学的一项任务。

Dosage monitoring through measurement of serum level--a task of clinical pharmacology.

作者信息

Walther H, Meyer F P, Quednow B, Leuschner U, Köhler E, Horenburg I

出版信息

Int J Clin Pharmacol Biopharm. 1978 Aug;16(8):387-90.

PMID:689799
Abstract

Dosage monitoring or "pharmacokinetic therapy service", respectively, covers blood level governed therapy schedule or blood level controlled dosage for certain types of therapy. It is also advantageous in applying drugs of a small therapeutic range or in "risk" patients such as children, old men and patients suffering from elimination disturbances. With the blood level data known, physicians can follow an optimum therapy schedule. The principle of this service is detailed using therapy with antiepileptics as an example. Through substantiation is given.

摘要

剂量监测或“药代动力学治疗服务”分别涵盖了某些类型治疗中根据血药浓度制定的治疗方案或血药浓度控制的剂量。在应用治疗窗较窄的药物时,或对于儿童、老年人以及存在消除功能障碍的“高危”患者而言,它也具有优势。在掌握血药浓度数据的情况下,医生能够遵循最佳治疗方案。以抗癫痫药物治疗为例详细阐述了这项服务的原理,并给出了依据。

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