Hossein Dialameh G
Int J Vitam Nutr Res. 1978;48(2):131-5.
The inhibition of enzymatic activity by the isomers of warfarin for alkylation of menaquinone-0 to menaquinone-4 has been studied in chick liver. Injection of (6,7--3H2)-menaquinone-0 into chicks resulted in the biosynthesis of menaquinone-4 within 3 h. Microsomes of control chicks contained 78 per cent of the total menaquinone-4. (S) (-)-Warfarin and (R) (+)-warfarin isomers inhibited the biosynthesis of menaquinone-4 of about 67 and 17 per cent respectively. Fractionation of soluble microsomal proteins lead to the the isolation of a menaquinone-4 binding protein.
在鸡肝脏中研究了华法林异构体对甲萘醌-0烷基化为甲萘醌-4的酶活性抑制作用。给雏鸡注射(6,7--³H₂)-甲萘醌-0后，3小时内即可生物合成甲萘醌-4。对照雏鸡的微粒体中含有总甲萘醌-4的78%。(S)-(-)-华法林和(R)-(+)-华法林异构体分别抑制甲萘醌-4生物合成约67%和17%。对可溶性微粒体蛋白进行分级分离，得到了一种甲萘醌-4结合蛋白。
