Nies A S, Rawl J, Cruze J, Oates J A, Frölich J C
Invest Urol. 1978 Jul;16(1):72-4.
We studied the effects of inhibiting prostaglandin synthesis on the renal blood flow and glomerular filtration rate of four conscious dogs with chronic unilateral renal artery stenosis. Dogs were prepared by exteriorizing the bladder trigone to allow repeated split renal function studies. Renal artery stenosis was produced with a Goldblatt clamp on one renal artery. Each of ten studies determined the function of each kidney in the conscious dog before and after indomethacin treatment. Administration of indomethacin resulted in a 90 per cent reduction of urinary prostaglandin E excretion, but no functional changes were produced in the kidney with the stenotic artery. These studies indicate that renal prostaglandins are not responsible for maintenance of creatinine and para-aminohippuric acid clearances after renal artery stenosis in the dog. However, the concentration gradient for creatinine between the stenotic and non-stenotic kidney was enhanced by indomethacin.
我们研究了抑制前列腺素合成对四只患有慢性单侧肾动脉狭窄的清醒犬的肾血流量和肾小球滤过率的影响。通过将膀胱三角区外置，使犬能够进行重复的分肾功能研究。用戈德布拉特夹钳夹闭一侧肾动脉造成肾动脉狭窄。十项研究中的每一项都测定了清醒犬在吲哚美辛治疗前后每个肾脏的功能。吲哚美辛给药导致尿前列腺素E排泄减少90%，但狭窄动脉侧的肾脏未产生功能变化。这些研究表明，在犬肾动脉狭窄后，肾前列腺素对维持肌酐和对氨基马尿酸清除率不起作用。然而，吲哚美辛增强了狭窄肾与非狭窄肾之间肌酐的浓度梯度。
