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[克莱恩-莱文-克里奇利综合征。对鉴别诊断问题解决的一项贡献(作者译)]

[The Kleine-Levin-Critchley-syndrome. A contribution to the solution of differential diagnosis (author's transl)].

作者信息

Hagel K, Freytag H, Kindt H

出版信息

Fortschr Neurol Psychiatr Grenzgeb. 1980 May;48(5):267-78. doi: 10.1055/s-2007-1002384.

Abstract

The typical symptoms of the so-called Kleine-Levin-Critchley-Syndrome are described according to our own observation of four selected patients (one woman, three men) on the background of the literature on the subject. In contrast to the first descriptions we characterise this syndrome by the Trias: periodic hypersomnia, vegetative disturbances (especially of food intake) and psychopathologic symptoms. Especially young men in their second decade of life suffer from this syndrome. As far as women are concerned the disease is found more seldom but the authors are sure that it exists. A spontaneous remission of the periodically proceeding disease often occurs in the third decade of life. In analogy to the respective literature a retardation of the EEG during the course of the disease going along with otherwise inconspicuous neurology was observed by the authors. Polygraphic-EEG studies are seldom. The cause of the syndrome is still open to question. Our observation show that a primarily disposition-linked and a secondarily acquisition-linked form can be assumed. Good effects are put down to amphetamines used for therapy. As far as differential diagnosis is concerned infections and abusus must be excluded.

摘要

根据我们对四名选定患者(一名女性,三名男性)的观察,并结合该主题的文献,描述了所谓克莱恩-莱文-克里奇利综合征的典型症状。与最初的描述不同,我们将该综合征的特征概括为三联征:周期性嗜睡、自主神经功能紊乱(尤其是食物摄入方面)和精神病理症状。尤其二十岁左右的年轻男性易患此综合征。就女性而言,该病较为少见,但作者确信其存在。这种周期性发作的疾病常在三十岁左右出现自发缓解。与相关文献类似,作者观察到在疾病过程中脑电图出现迟缓,而其他方面神经学表现不明显。多导脑电图研究很少。该综合征的病因仍存疑问。我们的观察表明,可以假定存在原发性易患倾向型和继发性后天获得型。治疗使用安非他明有良好效果。在鉴别诊断方面,必须排除感染和滥用情况。

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