Colman R W
Ann Clin Lab Sci. 1980 May-Jun;10(3):220-6.
The properties of the contact factors, factor XII, high molecular weight kininogen and prekallikrein are described as well as the abnormalities in the hereditary deficiencies of these proteins. The interactions of each of these proteins with the other as well as their regulation by plasma proteolytic inhibitors such as Cl inhibitor and antithrombin III are delineated. Biochemical techniques for measuring this system are discussed. Conditions associated with abnormal synthesis of these proteins are described. Diseases in which increased kinin formation has been documented as well as disorders where there is strong evidence for the activation of kallikrein are presented. Further knowledge of this system should increase our understanding of its pathophysiological alterations.
描述了接触因子、因子 XII、高分子量激肽原和前激肽释放酶的特性，以及这些蛋白质遗传性缺乏时的异常情况。阐述了这些蛋白质彼此之间的相互作用，以及它们如何受到血浆蛋白水解抑制剂如 C1 抑制剂和抗凝血酶 III 的调节。讨论了测量该系统的生化技术。描述了与这些蛋白质合成异常相关的情况。介绍了已记录到激肽形成增加的疾病，以及有充分证据表明激肽释放酶被激活的病症。对该系统的进一步了解应能增进我们对其病理生理改变的认识。
