Saito H
Adv Intern Med. 1980;25:217-38.
In the last 10 years, our understanding of the contact system, particularly its biochemistry, has greatly increased. The components of this system and their interactions have been elucidated from in vitro experiments. Although the activation of the contact system have been implicated in various types of human disease, in only a few instances is its role clearly defined. The physiologic role of the contact system is totally unknown at present. Obviously, more studies are needed to bridge a big gap between in vitro observations and in vivo phenomena.
在过去十年中，我们对接触系统，尤其是其生物化学的理解有了极大的提高。该系统的组成成分及其相互作用已通过体外实验得以阐明。尽管接触系统的激活与多种人类疾病有关，但只有少数情况下其作用得到明确界定。目前，接触系统的生理作用完全未知。显然，需要更多研究来弥合体外观察与体内现象之间的巨大差距。
