Kraly F S, Carty W J, Resnick S, Smith G P
J Comp Physiol Psychol. 1978 Aug;92(4):697-707. doi: 10.1037/h0077501.
After 3-hr food deprivation, rats with gastric fistulas ate liquid food with the fistula closed (normal feeding) or open (sham feeding). Meal size (MS) was larger, latency to rest (LR) after a meal was longer, and intermeal interval (IMI) was shorter during sham feeding than during normal feeding. The putative satiety signal cholecystokinin (CCK, 20% pure) decreased MS and LR and increased IMI during sham feeding. After CCK (30 U/kg) the MS, LR, and IMI were the same during sham feeding as during normal feeding. The synthetic octapeptide (OCT) of CCK, which has the known biological actions of the complete hormone, reproduced the effects of CCK (30 U/kg) on MS and LR but not on IMI. Ingestive behavior was not nonspecifically suppressed by CCK or OCT because water drinking was not inhibited by CCK or OCT. The CCK and OCT were also tested for their ability to serve as unconditioned stimuli (UCS) for the formation of a conditioned taste aversion (CTA) in the 3-hr food-deprived sham-feeding rat. The OCT (30 U/kg) did not serve as a UCS for a CTA in the same sham-feeding conditions in which OCT produced normal MS and LR. Impure CCK (30 U/kg), however, did serve as a UCS for a CTA under these conditions. The differential effectiveness of CCK and OCT for IMI and CTA may be due to non-CCK factors in the impure extract of CCK. These experiments demonstrate that the preabsorptive food-contingent stimuli of sham feeding plus exogenous CCK are sufficient for normal short-term satiety under certain conditions, and they provide further evidence consistent with the hypothesis that cholecystokinin produces satiety in rats.
禁食3小时后，患有胃瘘的大鼠在瘘管闭合（正常进食）或开放（假饲）的情况下进食流质食物。与正常进食相比，假饲期间的进食量（MS）更大，进食后休息潜伏期（LR）更长，餐间间隔（IMI）更短。假定的饱腹感信号胆囊收缩素（CCK，纯度20%）在假饲期间可减少MS和LR，并增加IMI。注射CCK（30 U/kg）后，假饲期间的MS、LR和IMI与正常进食期间相同。CCK的合成八肽（OCT）具有完整激素的已知生物学作用，它重现了CCK（30 U/kg）对MS和LR的影响，但对IMI没有影响。CCK或OCT不会非特异性地抑制摄食行为，因为饮水不受CCK或OCT的抑制。还测试了CCK和OCT作为非条件刺激（UCS）在禁食3小时的假饲大鼠中形成条件性味觉厌恶（CTA）的能力。在OCT产生正常MS和LR的相同假饲条件下，OCT（30 U/kg）不能作为CTA的UCS。然而，在这些条件下，不纯的CCK（30 U/kg）确实可作为CTA的UCS。CCK和OCT对IMI和CTA的不同有效性可能是由于CCK不纯提取物中的非CCK因子。这些实验表明，在某些条件下，假饲的吸收前食物相关刺激加上外源性CCK足以产生正常的短期饱腹感，并且它们提供了进一步的证据支持胆囊收缩素在大鼠中产生饱腹感的假说。
