Slots J, Evans R T, Lobbins P M, Genco R J
Antimicrob Agents Chemother. 1980 Jul;18(1):9-12. doi: 10.1128/AAC.18.1.9.
The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less than or equal to 2 micrograms/ml; 89% of the strains were inhibited by 2 micrograms of carbenicillin per ml. The other antimicrobial agents tested were less active. Approximately 10% of the A. actinomycetemcomitans strains were resistant to ampicillin, erythromycin, and penicillin G at concentrations of 32 to 64 micrograms/ml. These data suggest that tetracycline and minocycline may be valuable drugs in the treatment of A. actinomycetemcomitans infections.
采用琼脂稀释法测定了57株口腔分离株和2株非口腔分离株放线共生放线杆菌的抗生素敏感性。四环素、米诺环素和氯霉素在浓度小于或等于2微克/毫升时可抑制96%以上的受试菌株；每毫升2微克的羧苄青霉素可抑制89%的菌株。所测试的其他抗菌剂活性较低。约10%的放线共生放线杆菌菌株对浓度为32至64微克/毫升的氨苄青霉素、红霉素和青霉素G耐药。这些数据表明，四环素和米诺环素可能是治疗放线共生放线杆菌感染的有效药物。
