Brodsky I, Fuscaldo A A, Erlick B J, Fuscaldo K E
J Natl Cancer Inst. 1977 Jul;59(1):61-7. doi: 10.1093/jnci/59.1.61.
The effect of busulfan therapy on the activity of oncornavirus-like particles and chromosome patterns in patients with polycythemia vera and essential thrombocythemia was studied. Three patients had pretreatment platelet counts greater than 1 million/microliter, abnormal bone marrow karyotypes, and electron microscopic and biochemical evidence of oncornavirus. The results demonstrated that in all 3 patients virus-like particles and reverse transcriptase-like activity could no longer be found in the platelets within 2-4 weeks after the initiation of busulfan treatment. The platelet count was still elevated at this point for each patient, although the count returned to normal levels within 2-3 weeks after virus-like activity was no longer detectable. The chromosome patterns, characterized by aneuploidy (30-50%) before treatment, improved after therapy.
研究了白消安疗法对真性红细胞增多症和原发性血小板增多症患者中类肿瘤病毒样颗粒活性及染色体模式的影响。三名患者治疗前血小板计数大于100万/微升，骨髓核型异常，并有类肿瘤病毒的电子显微镜和生化证据。结果表明，在开始白消安治疗后的2 - 4周内，所有3名患者的血小板中均未再发现病毒样颗粒和逆转录酶样活性。此时每位患者的血小板计数仍处于升高状态，尽管在病毒样活性不再可检测到后的2 - 3周内计数恢复到了正常水平。治疗前以非整倍体（30 - 50%）为特征的染色体模式在治疗后有所改善。
