人、豚鼠和犬补体蛋白的溶血等效性。
The hemolytic equivalence of human, guinea pig and canine complement proteins.
作者信息
Sargent A U, Johnson S B
出版信息
Immunol Commun. 1980;9(5):453-63. doi: 10.3109/08820138009066008.
The ability of functionally pure human, guinea pig and canine complement proteins to fulfill the hemolytic function of a substituted analagous component in an otherwise totally homogeneous complement sequence was investigated by means of conventional hemolytic assays. A striking feature was the observation that for hemolysis to occur, differing requirements for enzyme-substrate homology were exhibited by each of the three species of C3 and C5 convertases (C3 and C5 CVA). The results suggest that different strategies of molecular interaction evolved in complement systems of different species.
通过传统的溶血试验，研究了功能纯的人、豚鼠和犬补体蛋白在其他方面完全均一的补体序列中替代类似成分实现溶血功能的能力。一个显著特征是观察到，三种C3和C5转化酶（C3和C5 CVA）中的每一种在溶血发生时，对酶-底物同源性都有不同的要求。结果表明，不同物种的补体系统进化出了不同的分子相互作用策略。
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