Hanks C T, Smith E O
J Invest Dermatol. 1978 Sep;71(3):172-6. doi: 10.1111/1523-1747.ep12547084.
Following the subcutaneous injection of a water soluble dermal extract (DE) of neonatal rat skin into young adult male rats, depression of nuclear labeling (DNA synthesis) was observed in proliferating connective tissue in several wound sites. At 16--20 hr following DE injection, DNA synthesis was depressed most in back wounds (57--87%) and maxillary palatal wounds (45--68%), and least in ear wounds (24--29%). Epithelium in the wound margins of back, ear and palate did not show a similar depression in DE-injected animals. This study suggests that a chalone-like negative feedback mechanism may be partially responsible for in vivo control of fibroblastic proliferation in wound healing.
将新生大鼠皮肤的水溶性真皮提取物（DE）皮下注射到成年雄性幼鼠体内后，在几个伤口部位的增殖性结缔组织中观察到核标记（DNA合成）受到抑制。在注射DE后16 - 20小时，背部伤口（57 - 87%）和上颌腭部伤口（45 - 68%）的DNA合成抑制最为明显，耳部伤口（24 - 29%）的抑制最不明显。在注射DE的动物中，背部、耳部和腭部伤口边缘的上皮细胞未表现出类似的抑制现象。这项研究表明，一种类抑素样的负反馈机制可能部分负责伤口愈合过程中体内成纤维细胞增殖的控制。
