Bourne K A, Major E O, Khoobyarian N
J Gen Virol. 1978 Sep;40(3):685-9. doi: 10.1099/0022-1317-40-3-685.
A variant of adenovirus type 12 (R-Ad12) has been isolated by infecting a clonal line of normal rat kidney cells (NRK) with wild-type adenovirus 12. Although R-Ad12 failed to produce infectious progeny virions when cycled a second time through NRK cells, it nevertheless retained the ability to code for virus structural proteins that accumulated in the cytoplasm.
通过用野生型腺病毒12感染正常大鼠肾细胞（NRK）的克隆系，分离出了腺病毒12的一种变体（R-Ad12）。尽管R-Ad12在再次通过NRK细胞传代时未能产生有感染性的子代病毒粒子，但它仍然保留了编码在细胞质中积累的病毒结构蛋白的能力。
