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大鼠小脑中的糖蛋白运输

Glycoprotein transport in the rat cerebellum.

作者信息

Langley O K, Carmichael N G

出版信息

J Neurocytol. 1978 Aug;7(4):479-88. doi: 10.1007/BF01173992.

DOI:10.1007/BF01173992
PMID:690674
Abstract

The fate of tritiated fucose in rat cerebellum has been followed using autoradiographic techniques for a period up to one week after intraventricular injection. At intervals of up to three hours after injection, Purkinje and granule cell bodies were found to be most heavily labelled. Subsequently this labelling declined and the highest grain density was observed over the molecular layer. The data is interpreted in terms of fucose incorporation into glycoproteins in nerve cell bodies followed by rapid dendritic transport in the Purkinje cell and fast transport in granule cells along ascending axons and parallel fibres.

摘要

利用放射自显影技术,在脑室内注射后长达一周的时间内追踪了氚标记岩藻糖在大鼠小脑中的去向。注射后间隔长达三小时,发现浦肯野细胞和颗粒细胞体标记最为明显。随后这种标记减少,在分子层观察到最高的颗粒密度。这些数据的解释是,岩藻糖先掺入神经细胞体中的糖蛋白,随后在浦肯野细胞中进行快速树突运输,在颗粒细胞中沿上升轴突和平行纤维进行快速运输。

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1
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