Cass A E, Hill H A
Ciba Found Symp. 1980;79:71-91. doi: 10.1002/9780470720622.ch5.
The copper proteins that function in homeostasis, electron transport, dioxygen transport and oxidation are discussed. Particular emphasis is placed on the role of the ligands, their type and disposition which, in conjunction with other residues in the active site, determine the role of the copper ion. It is proposed that copper proteins can be considered in four groups. Those in Group I contain a single copper ion in an approximately tetrahedral environment with nitrogen and sulphur-containing ligands. Group II proteins have a single copper ion in a square-planar-like arrangement. Group III proteins have two copper ions in close proximity. Group IV consists of multi-copper proteins, composed of sites representative of the other three groups.
本文讨论了在体内平衡、电子传递、双氧运输和氧化过程中发挥作用的铜蛋白。特别强调了配体的作用、其类型和分布，这些与活性位点中的其他残基共同决定了铜离子的作用。有人提出，铜蛋白可分为四类。第一类中的铜蛋白在一个由含氮和含硫配体构成的近似四面体环境中含有单个铜离子。第二类蛋白中的单个铜离子呈类平面正方形排列。第三类蛋白中有两个相邻的铜离子。第四类由多铜蛋白组成，其包含代表其他三类的位点。
