Effect of surfactants on percutaneous absorption of naproxen I: comparisons of rabbit, rat, and human excised skin.

The in vitro skin penetration model using excised skin from rats, rabbits, and humans was examined to evaluate the relative effect of surfactants on percutaneous absorption of naproxen. Differences in the magnitude of the effect of surfactants in promoting percutaneous absorption of naproxen through skins of different species were observed. For comparative evaluations of the formulation effects on percutaneous absorption, such as the effect of surfactants, in vitro studies with animal skin may not provide information in agreement with in vitro human skin.