Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.
作者信息
Ramachander G, Bapatla K R, Emele J F
出版信息
J Pharm Sci. 1978 Sep;67(9):1326-7. doi: 10.1002/jps.2600670939.
PMID:690847
Abstract
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.
摘要
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