给予右美沙芬的大鼠中右啡烷血浆半衰期的性别差异。
Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.
作者信息
Ramachander G, Bapatla K R, Emele J F
出版信息
J Pharm Sci. 1978 Sep;67(9):1326-7. doi: 10.1002/jps.2600670939.
PMID:690847
Abstract
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.
摘要
雄性和雌性大鼠在代谢右美沙芬的能力上表现出显著差异。口服这种药物后，去甲右美沙芬（一种通过O-去甲基化形成的主要生物转化产物）在雌性大鼠中的血浆半衰期为40分钟，在雄性大鼠中为18.5分钟。
Zotero 插件