新化合物：3β-羟基-13α-氨基-13,17-开环-5α-雄甾烷-17-酸-13,17-内酰胺4-[对-[双(2-氯乙基)氨基]苯基]丁酸酯的抗肿瘤活性
New compounds: antitumor activity of 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate.
作者信息
Catsoulacos P, Politis D, Boutis L, Papageorgiou A
出版信息
J Pharm Sci. 1978 Sep;67(9):1342-3. doi: 10.1002/jps.2600670948.
PMID:690853
Abstract
3beta-Hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p[bis(2chloroethyl)amino]phenyl]butyrate was prepared by reacting 4-[p-[bis(2-chloroethyl)amino]phenyl]butyryl chloride hydrochloride with 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam. They cytostatic action of the ester was investigated on two tumor systems (B16 melanoma on C57 b1 mice and T8-Guerin on rats).
摘要
通过使4-[对-[双(2-氯乙基)氨基]苯基]丁酰氯盐酸盐与3β-羟基-13α-氨基-13,17-断-5α-雄甾烷-17-酸-13,17-内酰胺反应制备了4-[对-[双(2-氯乙基)氨基]苯基]丁酸-3β-羟基-13α-氨基-13,17-断-5α-雄甾烷-17-酸-13,17-内酰胺。在两种肿瘤模型（C57 b1小鼠的B16黑色素瘤和大鼠的T8-卡介苗）上研究了该酯的细胞抑制作用。
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