大鼠在生理盐水、甘露醇、葡萄糖和尿素利尿过程中的自由水清除曲线。

Free water clearances were measured during infusion of hypotonic saline, glucose, urea, and mannitol in Brattleboro rats. For each solute the free water clearances were plotted using either V or (C(H2O) + C(Na)) as the distal tubular delivery term.2. In all cases the use of (C(H2O) + C(Na)) as distal delivery term yielded a steeper relationship than when V was used. There were no significant differences in the C(H2O) to V relationship when saline, glucose and mannitol was the solute infused. Urea, however, resulted in a curve with a slope significantly less than that for the other solutes.3. When C(H2O) was plotted against (C(H2O) + C(Na)) there was still no significant difference between the slopes of the curves during saline or mannitol infusion. Use of this delivery term, however, resulted in a slope during glucose infusion which was significantly greater than that during saline or mannitol infusion. The slope for urea infusion remained lower than that for any other solute.4. Regardless of the delivery term used, there was no significant difference in the slopes of the curves for awake Wistar and awake Brattleboro rats during mannitol infusion. This indicates that the awake rat is a suitable model for free water clearance studies.5. The results indicate that NaCl and mannitol are both adequate for free water clearance and that (C(H2O) + C(Na)) is a better index of distal delivery than V.

在向布拉德福德大鼠输注低渗盐水、葡萄糖、尿素和甘露醇期间，测量了自由水清除率。对于每种溶质，使用V或（C（H₂O）+C（Na））作为远端肾小管输送指标来绘制自由水清除率曲线。
在所有情况下，使用（C（H₂O）+C（Na））作为远端输送指标时得到的关系曲线比使用V时更陡峭。当输注的溶质为盐水、葡萄糖和甘露醇时，C（H₂O）与V的关系曲线没有显著差异。然而，尿素导致的曲线斜率明显小于其他溶质的曲线斜率。
当以C（H₂O）对（C（H₂O）+C（Na））作图时，在输注盐水或甘露醇期间曲线的斜率之间仍然没有显著差异。然而，使用这个输送指标时，葡萄糖输注期间的斜率明显大于盐水或甘露醇输注期间的斜率。尿素输注的斜率仍然低于任何其他溶质的斜率。
无论使用何种输送指标，在输注甘露醇期间，清醒的Wistar大鼠和清醒的布拉德福德大鼠曲线的斜率没有显著差异。这表明清醒大鼠是自由水清除率研究的合适模型。
结果表明，NaCl和甘露醇都适用于自由水清除率研究，并且（C（H₂O）+C（Na））是比V更好的远端输送指标。

Free water clearance curves during saline, mannitol, glucose and urea diuresis in the rat.