8-羧基-6-氨磺酰基二苯并[b,f][1,4]恶唑嗪类和噻嗪类作为潜在的高效能利尿剂。
8-Carboxy-6-sulfamyldibenz[b,f][1,4]oxazepines and -thiazepines as potential high-ceiling diuretics.
作者信息
Allen R C, Reitano P A, Urbach H
出版信息
J Med Chem. 1978 Aug;21(8):838-40. doi: 10.1021/jm00206a027.
PMID:691010
Abstract
The synthesis of several 8-carboxy-6-sulfamyldibenz[b,f][1,4]oxazepines and -thiazepines is described. The results of diuretic screening lend support to the thesis that activity is strongly dependent on the conformational mobility of 4-substituents in the 3-amino-5-sulfamylbenzoic acids.
摘要
本文描述了几种8-羧基-6-氨磺酰基二苯并[b,f][1,4]噁二氮杂䓬和二苯并[b,f][1,4]噻二氮杂䓬的合成。利尿筛选结果支持了以下论点：活性强烈依赖于3-氨基-5-氨磺酰基苯甲酸中4-取代基的构象流动性。
相似文献
1
8-Carboxy-6-sulfamyldibenz[b,f][1,4]oxazepines and -thiazepines as potential high-ceiling diuretics.8-羧基-6-氨磺酰基二苯并[b,f][1,4]恶唑嗪类和噻嗪类作为潜在的高效能利尿剂。
J Med Chem. 1978 Aug;21(8):838-40. doi: 10.1021/jm00206a027.
2
Aminobenzoic acid diuretics. 5. 3-Amino-4-arylmethyl-5-sulfamylbenzoic acid derivatives and related compounds.
J Med Chem. 1973 Oct;16(10):1170-7. doi: 10.1021/jm00268a022.
3
Aminobenzoic acid diuretics. 7. 3-Substituted 4-phenyl-, 4-arylcarbonyl-, and 4-arylmethyl-5-sulfamoylbenzoic acids and related compounds.
J Med Chem. 1975 Jan;18(1):41-50. doi: 10.1021/jm00235a010.
4
Aminobenzoic acid diuretics. 6. 4-Substituted 3-alkylthio-5-sulfamoylbenzoic and 5-sulfamoylthiosalicylic acids.
J Med Chem. 1974 Jun;17(6):572-8. doi: 10.1021/jm00252a002.
5
2,3-Disubstituted 1,6-naphthyridines as potential diuretic agents.作为潜在利尿剂的2,3-二取代1,6-萘啶
J Med Chem. 1973 Jul;16(7):849-53. doi: 10.1021/jm00265a024.
6
Aminobenzoic acid diuretics. 4. 4-Benzyl-5-sulfamylanthranilic acid derivatives and related 1,2-benzisothiazole 1,1-dioxides.
J Med Chem. 1973 Feb;16(2):127-30. doi: 10.1021/jm00260a010.
7
(Vinylaryloxy)acetic acids. A new class of diuretic agents. 4. Various ((2-substituted and 2,2-disubstituted vinyl)aryloxy)acetic acids.
J Med Chem. 1976 Jul;19(7):972-5. doi: 10.1021/jm00229a024.
8
Diuretics. 1. 1-Imidoyl-2-(2- and 3-indoly)indolines.
J Med Chem. 1972 May;15(5):529-34. doi: 10.1021/jm00275a023.
9
Quinuclidine chemistry. 4. Diuretic properties of cis-3-amino-2-benzhydrylquinuclidine.
J Med Chem. 1975 Jun;18(6):587-93. doi: 10.1021/jm00240a013.
10
[Chemical structure and diuretic effect in the series of 4-chloro-3-sulfonamide-benzolsulfonamide].[4-氯-3-磺酰胺基苯磺酰胺系列的化学结构与利尿作用]
Arzneimittelforschung. 1967 Jun;17(6):653-9.
Zotero 插件