Infante P F, Rinsky R A, Wagoner J K, Young R J
Lancet. 1977 Jul 9;2(8028):76-8. doi: 10.1016/s0140-6736(77)90074-5.
Workers occupationally exposed to benzene in 1940-49 were followed for vital status up to 1975. In comparison with two control populations, a significant (P less than 0-002) excess of leukaemia was observed. A five-old excessive risk of all leukaemias and a ten-fold excess of deaths from myeloid and monocytic leukaemias combined are demonstrated in the study population compared with controls. These figures under-estimate the true leukaemia risk to benzene-exposed workers, because follow-up is only 75% complete and the untraced 25% of the study population were all regarded, in the statistical analysis, as being alive at the end of the study period. The environment of the workers in the study population was not contaminated with solvents other than benzene, and existing records indicate that the benzene levels themselves were generally below the limits recommended at the time of their measurement.
对1940年至1949年职业性接触苯的工人进行了随访，直至1975年了解其生命状况。与两个对照人群相比，观察到白血病显著（P小于0.002）超额。研究人群与对照组相比，所有白血病的风险高出五倍，髓系和单核细胞白血病合并死亡的风险高出十倍。这些数字低估了接触苯工人患白血病的真实风险，因为随访仅完成了75%，在统计分析中，未追踪到的25%的研究人群在研究期结束时都被视为存活。研究人群中工人的工作环境除苯以外未被其他溶剂污染，现有记录表明，苯水平本身通常低于测量时推荐的限值。
