一项针对职业性接触苯的化工工人的全行业死亡率研究。II. 剂量反应分析。
An industry wide mortality study of chemical workers occupationally exposed to benzene. II. Dose response analyses.
作者信息
Wong O
出版信息
Br J Ind Med. 1987 Jun;44(6):382-95. doi: 10.1136/oem.44.6.382.
Abstract
The data presented in this paper show statistically significant dose response relations between cumulative exposure to benzene (ppm-months) and mortality from both all lymphopoietic cancer combined and leukaemia. Chemical workers with a cumulative exposure to benzene of at least 720 ppm-months experienced a relative risk of 3.93 for lymphatic and haematopoietic cancer when compared with workers with no occupational exposure. The dose response relation between cumulative exposure and non-Hodgkin's lymphopoietic cancer was of borderline statistical significance (p = 0.06). No dose response relation was detected for any other causes of death.
摘要
本文所呈现的数据表明，苯的累积暴露量（ppm-月）与所有淋巴造血系统癌症合并死亡率以及白血病死亡率之间存在具有统计学意义的剂量反应关系。累积接触苯至少达720 ppm-月的化学工人，与无职业暴露的工人相比，患淋巴和造血系统癌症的相对风险为3.93。累积暴露与非霍奇金淋巴造血系统癌症之间的剂量反应关系具有临界统计学意义（p = 0.06）。未检测到其他任何死因的剂量反应关系。
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本文引用的文献
1
Statistical aspects of the analysis of data from retrospective studies of disease.疾病回顾性研究数据的统计分析方面
J Natl Cancer Inst. 1959 Apr;22(4):719-48.
2
A case-control study of occupational exposures and leukaemia.一项关于职业暴露与白血病的病例对照研究。
Int J Epidemiol. 1980 Jun;9(2):131-5. doi: 10.1093/ije/9.2.131.
3
Leukemia in benzene workers.苯作业工人中的白血病。
Am J Ind Med. 1981;2(3):217-45. doi: 10.1002/ajim.4700020305.
4
Mortality among chemical workers exposed to benzene and other agents.接触苯及其他制剂的化学工人的死亡率。
Environ Res. 1983 Feb;30(1):16-25. doi: 10.1016/0013-9351(83)90161-5.
5
An industry wide mortality study of chemical workers occupationally exposed to benzene. I. General results.一项针对职业性接触苯的化工工人的全行业死亡率研究。I. 总体结果。
Br J Ind Med. 1987 Jun;44(6):365-81. doi: 10.1136/oem.44.6.365.
6
Mortality among individuals occupationally exposed to benzene.
Arch Environ Health. 1978 Jan-Feb;33(1):3-10. doi: 10.1080/00039896.1978.10667299.
7
Retrospective industrial hygiene surveys.
Am Ind Hyg Assoc J. 1979 Jan;40(1):58-65. doi: 10.1080/15298667991429327.
8
Benzene and leukemia.
Lancet. 1978 Feb 25;1(8061):441. doi: 10.1016/s0140-6736(78)91226-6.
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