Black C M, Welsh K I, Fielder A, Hughes G R, Batchelor J R
Tissue Antigens. 1982 Feb;19(2):115-20. doi: 10.1111/j.1399-0039.1982.tb01426.x.
The clinical features and HLA types of 67 unrelated patients with Systemic Lupus Erythematosus (SLE) were analyzed. The results showed: 1. An increase in frequencies of A1, B8, and DR3. These antigens are in close linkage disequilibrium and our data show that susceptibility to SLE is associated with the presence of all three antigens, implicating the specific haplotype which bears these antigens. 2. An increase in frequency of DR2, but not A3 or B7, these latter two antigens being in linkage disequilibrium with DR2. 3. 73.3% of the 54 Caucasoid SLE group were either B8 and/or DR2. This is in comparison with 37.5% in the controls and the difference is significant (p less than 0.001). 4. There was no association apparent between extent of disease, particular organ involvement and level of circulating antibodies to double stranded DNA with any HLA region product.
对67例非亲属系统性红斑狼疮（SLE）患者的临床特征和HLA类型进行了分析。结果显示：1. A1、B8和DR3频率增加。这些抗原处于紧密连锁不平衡状态，我们的数据表明，SLE易感性与所有这三种抗原的存在相关，这意味着携带这些抗原的特定单倍型。2. DR2频率增加，但A3或B7频率未增加，后两种抗原与DR2处于连锁不平衡状态。3. 54例白种人SLE组中73.3%为B8和/或DR2。相比之下，对照组为37.5%，差异有统计学意义（p小于0.001）。4. 疾病程度、特定器官受累情况与双链DNA循环抗体水平与任何HLA区域产物之间均无明显关联。
