Whittingham S, Mathews J D, Schanfield M S, Tait B D, Mackay I R
Tissue Antigens. 1983 Jan;21(1):50-7. doi: 10.1111/j.1399-0039.1983.tb00372.x.
HLA and Gm phenotypes were compared in 53 patients with unequivocal systemic lupus erythematosus (SLE) and in 180 healthy subjects. SLE was associated with HLA-B8 (relative risk (RR) = 3.5, P less than 0.001) and with HLA-DR3 (RR = 2.8, P less than 0.01). There was an increased risk of SLE with HLA-B8/B27 (RR = 27.6) and with HLA-B15/B35 (RR greater than 13) and, in contrast, the risk was decreased in subjects with HLA-B40 (RR = 0.3). The risk of SLE in subjects who were heterozygous for the Gm phenotypes a,f,x; b,g was increased (RR = 2.0, P = 0.03) relative to the risk in subjects who were homozygous for these Gm phenotypes. These findings suggest that susceptibility to SLE is influenced by one or more genes in linkage disequilibrium with the HLA-B8-DR3 haplotype, by "augmentor" or "protector" genes associated with other HLA antigens and by separate genes, possibly VH genes, in linkage disequilibrium with the Gm (CH allotype) locus.
对53例确诊的系统性红斑狼疮（SLE）患者和180名健康受试者的HLA和Gm表型进行了比较。SLE与HLA - B8（相对风险（RR）= 3.5，P < 0.001）和HLA - DR3（RR = 2.8，P < 0.01）相关。HLA - B8/B27（RR = 27.6）和HLA - B15/B35（RR > 13）的SLE风险增加，相反，HLA - B40的受试者风险降低（RR = 0.3）。相对于这些Gm表型纯合子的受试者，Gm表型a、f、x；b、g杂合子的受试者患SLE的风险增加（RR = 2.0，P = 0.03）。这些发现表明，SLE易感性受与HLA - B8 - DR3单倍型处于连锁不平衡的一个或多个基因、与其他HLA抗原相关的“增强子”或“保护者”基因以及与Gm（CH同种异型）位点处于连锁不平衡的单独基因（可能是VH基因）的影响。
