Levy D L, Cox A, Leffell M S, Wilds P L
Am J Reprod Immunol (1980). 1982 Jun;2(3):142-7. doi: 10.1111/j.1600-0897.1982.tb00155.x.
Physiologic changes occurring during the latent period of prematurely ruptured membranes (PRM) are poorly understood. Indicators predicting maternal and neonatal infectious morbidity do not correlate well with clinical outcomes. A previous report suggested that in vivo complement consumption occurred in response to the event of membrane rupture. In this prospective study, complement activity was measured serially throughout the latent period in cases of preterm PRM. In addition to total hemolytic complement activity (CH50), C4-pro-activator (C3PA), a primary component of the alternate complement pathway, was measured in maternal and cord sera. As with CH50, cord serum C3PA levels are significantly less than those in matched maternal samples. Neither maternal nor cord serum complement activity correlated with either the duration of the latent period or maternal-neonatal infection.
胎膜早破（PRM）潜伏期发生的生理变化尚不清楚。预测母婴感染发病率的指标与临床结果的相关性不佳。先前的一份报告表明，体内补体消耗是对胎膜破裂事件的反应。在这项前瞻性研究中，对早产胎膜早破病例在整个潜伏期连续测量补体活性。除了总溶血补体活性（CH50）外，还在母血和脐血血清中测量了替代补体途径的主要成分C4-前激活剂（C3PA）。与CH50一样，脐血血清C3PA水平明显低于匹配的母血样本。母血和脐血血清补体活性均与潜伏期或母婴感染的持续时间无关。
