Huffaker J, Witkin S S, Cutler L, Druzin M L, Ledger W J
Department of Obstetrics and Gynecology, New York Hospital-Cornell University Medical Center, New York.
Surg Gynecol Obstet. 1989 May;168(5):397-401.
Total hemolytic complement activity (CH50) was determined in maternal sera, amniotic fluids or cord sera, or all, from 119 patients with preterm uterine contractions, premature rupture of membranes or chorioamnionitis, or all, at 24 to 40 weeks of gestation. The mean CH50 of maternal sera exceeded the mean CH50 of both amniotic fluids and cord sera. The mean CH50 of amniotic fluids exceeded that of cord sera and increased significantly at 32 weeks. This rise preceded that of the mean CH50 of cord sera, which occurred at a fetal weight of approximately 2,500 grams. The mean CH50 of amniotic fluids varied significantly and inversely with that of cord sera. The levels of CH50 in these three fluids did not distinguish between patients with preterm uterine contractions who delivered prematurely and those who delivered at term. The CH50 in patients with premature rupture of membranes did not differ from a control population of women with uncomplicated pregnancies. The mean CH50 of maternal sera was increased in patients with chorioamnionitis but was not predictive of chorioamnionitis. The mean CH50 of maternal sera was decreased in patients who smoked cigarettes and in patients who received intravenous ritodrine.
在119例妊娠24至40周出现子宫收缩过早、胎膜早破或绒毛膜羊膜炎，或同时出现上述情况的患者中，检测其母血、羊水或脐血，或所有这些样本的总溶血补体活性（CH50）。母血的平均CH50超过羊水和脐血的平均CH50。羊水的平均CH50超过脐血，且在孕32周时显著升高。这种升高先于脐血平均CH50的升高，脐血平均CH50的升高发生在胎儿体重约2500克时。羊水的平均CH50与脐血的平均CH50显著负相关。这三种液体中CH50的水平无法区分早产子宫收缩且早产的患者和足月分娩的患者。胎膜早破患者的CH50与正常妊娠女性对照组无差异。绒毛膜羊膜炎患者母血的平均CH50升高，但不能预测绒毛膜羊膜炎。吸烟患者和接受静脉注射利托君的患者母血的平均CH50降低。
