Zhadkevich M M, Bagdat'ev V E, Kubyshkin V A
Biull Eksp Biol Med. 1982 Aug;94(8):27-30.
Experiments were made on 22 anesthetized dogs to examine the systemic and pulmonary hemodynamics, gas exchange and metabolic pulmonary function in pancreonecrosis. Metabolic pulmonary function was evaluated from arteriovenous difference according to elastase. In the early stages of experimental pancreatitis, the lungs were shown to inactivate elastase and to function as an active metabolic organ. Then depletion of antienzymatic pulmonary function is observed, which is accompanied by decompensation of the hemodynamics and gas exchange. Abnormality of antienzymaztic pulmonary function plays an important role in the pathogenesis of acute pancreatitis.
对22只麻醉犬进行实验，以研究胰腺坏死时的全身和肺血流动力学、气体交换及肺代谢功能。根据弹性蛋白酶的动静脉差值评估肺代谢功能。在实验性胰腺炎早期，肺可使弹性蛋白酶失活并作为一个活跃的代谢器官发挥作用。随后观察到肺抗酶功能耗竭，同时伴有血流动力学和气体交换失代偿。肺抗酶功能异常在急性胰腺炎发病机制中起重要作用。
