Pearse B M
Ciba Found Symp. 1982(92):246-65. doi: 10.1002/9780470720745.ch12.
Purified coated vesicles typically contain clathrin and auxiliary structural proteins of about 100 000 and 50 000 relative molecular mass (Mr). A model is described for the packing of clathrin trimers into the characteristic pentagons and hexagons of the surface lattices of coats. In a coated vesicle, clathrin appears to bind to an inner 'core' of particles containing the 100 000 and 50 000 Mr proteins. These core proteins may, in turn, bind to receptors in the membrane of the vesicle. The vesicle itself surrounds specific content molecules bound to their respective receptors. Budding coated vesicles are believed to act as molecular filters in cells. The known structural features of coated membranes are discussed in terms of this apparent role.
纯化的包被小泡通常含有相对分子质量（Mr）约为100000和50000的网格蛋白及辅助结构蛋白。本文描述了一种将网格蛋白三聚体包装成包被表面晶格特征性五边形和六边形的模型。在包被小泡中，网格蛋白似乎与含有100000和50000 Mr蛋白的颗粒内部“核心”结合。这些核心蛋白可能进而与小泡膜上的受体结合。小泡本身围绕着与其各自受体结合的特定内含物分子。出芽的包被小泡被认为在细胞中起分子过滤器的作用。本文根据这一明显作用讨论了包被膜的已知结构特征。
