Pollard J D, Harrison B, Gatenby P
Clin Exp Neurol. 1981;18:70-80.
Serum from rabbits with EAN in the acute phase of the disease has been injected into rat sciatic nerve, and compared to control rabbit serum and serum from patients with demyelinating neuropathy and to normal human control serum. Electrophysiological studies were performed on all rat sciatic nerves so injected, and the nerve was then removed and examined histologically. Control rabbit and human serum and neuropathic human serum, when injected in a 20 microL quantity through a 30 gauge needle, did not produce significant electrophysiological abnormalities. EAN serum, however, produced significant dispersion of the muscle action potential and conduction block. All serum produced some histological evidence of demyelination but that seen with EAN serum was quite profound compared to all other sera. It is concluded that humoral factors are present within animals with EAN which has potent demyelinating potential. We were not able to demonstrate the same effect from patients with demyelinating neuropathy in this test system.
已将疾病急性期患有实验性变态反应性神经炎（EAN）的兔子的血清注入大鼠坐骨神经，并与对照兔血清、脱髓鞘性神经病患者的血清以及正常人对照血清进行比较。对所有如此注入血清的大鼠坐骨神经进行电生理研究，然后取出神经并进行组织学检查。当通过30号针头注入20微升对照兔血清、人血清和神经性人血清时，未产生明显的电生理异常。然而，EAN血清导致肌肉动作电位明显离散和传导阻滞。所有血清均产生了一些脱髓鞘的组织学证据，但与所有其他血清相比，EAN血清导致的脱髓鞘现象相当严重。结论是，患有EAN的动物体内存在具有强大脱髓鞘潜力的体液因子。在该测试系统中，我们未能证明脱髓鞘性神经病患者的血清有同样的效果。
