Misra L K, Kasturi S R, Kundu S K, Harati Y, Hazlewood C F, Luthra M G, Yamanashi W S, Munjaal R P, Amtey S R
Magn Reson Imaging. 1982;1(2):75-9. doi: 10.1016/0730-725x(82)90222-3.
Nuclear magnetic resonance (NMR) techniques were applied to study the muscular dystrophy in chicks. The water proton spin-lattice relaxation times (T1) of fast, slow, and mixed muscles and plasma were measured. The T1 values of dystrophic pectoralis major and posterior latissimus dorsi (PLD) were significantly higher than those of the normal pectoralis and PLD muscles. The present results establish a direct relationship between the differences in T1 values and the severity of muscle degeneration. Consistent with this conclusion, it was also found that the T1 values of muscles unaffected in muscular dystrophy, namely, the gastrocnemius, and anterior latissimus dorsi (ALD), were not different between the normal and dystrophic chicks. Although the affected muscles of dystrophic chicks contained higher percent water and fat than those of normal chicks, the results show that the higher T1 values in dystrophic muscles were not solely due to variations in their water content. The increase in the T1 values is principally a result of altered interaction between cellular water and macromolecules in the diseased muscles. These data also point out the potential use of NMR imaging in evaluating muscle degeneration.
应用核磁共振（NMR）技术研究雏鸡的肌肉萎缩症。测量了快肌、慢肌、混合肌以及血浆中的水质子自旋 - 晶格弛豫时间（T1）。患肌肉萎缩症的胸大肌和背阔肌后部（PLD）的T1值显著高于正常胸大肌和PLD肌肉的T1值。目前的结果证实了T1值差异与肌肉退化严重程度之间存在直接关系。与此结论一致的是，还发现肌肉萎缩症未受影响的肌肉，即腓肠肌和背阔肌前部（ALD），在正常雏鸡和患肌肉萎缩症的雏鸡之间T1值并无差异。尽管患肌肉萎缩症的雏鸡受影响的肌肉比正常雏鸡的肌肉含有更高比例的水和脂肪，但结果表明，患肌肉萎缩症的肌肉中较高的T1值并非仅仅归因于其含水量的变化。T1值的增加主要是患病肌肉中细胞内水与大分子之间相互作用改变的结果。这些数据还指出了NMR成像在评估肌肉退化方面的潜在用途。
