正常肌肉与营养不良性肌肉之间T1信号增强的差异。

Enhanced T1 differentiation between normal and dystrophic muscles.

作者信息

Misra L K, Luthra M G, Amtey S R, Elizondo-Riojas G, Swezey S H, Todd L E

出版信息

Magn Reson Imaging. 1984;2(1):33-5. doi: 10.1016/0730-725x(84)90122-x.

Abstract

Proton spin-lattice relaxation times (T1) of pectoralis major muscles from normal (Line 412) and homozygous dystrophic (Line 413) chicks was measured by FONAR QED 80 at 1.69 MHz. The T1 values of dystrophic muscles (216.8 +/- 17.3 ms) was two-fold higher than those of normal muscles (110.2 +/- 8.1 msec). When these values were compared with the T1 values obtained at high frequencies (20 MHz and 32 MHz), the T1 differentiation between normal and dystrophic muscles was considerably enhanced at 1.69 MHz. Based on these results, we suggest that the high resolution of T1 obtained at low frequency (1.69 MHz) could be effectively used to detect the degenerative processes in muscles by the NMR techniques.

摘要

使用FONAR QED 80在1.69兆赫兹下测量了正常（412系）和纯合性营养不良（413系）雏鸡胸大肌的质子自旋-晶格弛豫时间（T1）。营养不良肌肉的T1值（216.8±17.3毫秒）比正常肌肉的T1值（110.2±8.1毫秒）高出两倍。当将这些值与在高频（20兆赫兹和32兆赫兹）下获得的T1值进行比较时，正常肌肉和营养不良肌肉之间的T1差异在1.69兆赫兹时显著增强。基于这些结果，我们认为在低频（1.69兆赫兹）下获得的T1高分辨率可通过核磁共振技术有效地用于检测肌肉中的退行性过程。