Bennett R, Batenhorst R, Graves D A, Foster T S, Griffen W O, Wright B D
Pharmacotherapy. 1982 Jan-Feb;2(1):50-3. doi: 10.1002/j.1875-9114.1982.tb03172.x.
Patient-controlled analgesia is a relatively new method of administering intravenous narcotics for postoperative pain relief. The technique involves the self-administration of a given analgesic in a bolus dose with the aid of a timed infusion and sequencing device. Ten morbidity obese patients undergoing elective gastric bypass surgery were treated in a prospective, unblinded, pilot project to evaluate the efficacy of patient-controlled analgesia. Analgesic therapy was satisfactory in all patients. The mean total dose of morphine sulfate administered during the first 36 hours postoperatively was 66 mg, an average of 1.7 mg/hr. There was a tenfold variation (17.5-175 mg) in the 36 hr total dose. The total dose was not related to body surface area, age, sex, dose per injection, or anesthetic agent. The large variation in individual narcotic analgesic requirements could be a major factor in the suboptimal management of postoperative pain with conventional dosing. Patient-controlled analgesia may circumvent these problems.
患者自控镇痛是一种相对较新的静脉注射麻醉剂用于术后疼痛缓解的方法。该技术涉及借助定时输注和排序装置自行推注一定剂量的镇痛剂。在一项前瞻性、非盲法的试点项目中，对10例接受择期胃旁路手术的肥胖患者进行了治疗，以评估患者自控镇痛的疗效。所有患者的镇痛治疗效果均令人满意。术后前36小时硫酸吗啡的平均总剂量为66毫克，平均每小时1.7毫克。36小时总剂量存在10倍的差异（17.5 - 175毫克）。总剂量与体表面积、年龄、性别、每次注射剂量或麻醉剂无关。个体对麻醉性镇痛药需求的巨大差异可能是传统给药方式术后疼痛管理欠佳的一个主要因素。患者自控镇痛可能会规避这些问题。
