潜在的抗肿瘤药物：带有烷基化部分的甾体酰胺酯。
Potential antitumor agents: steroidal amidoesters with an alkylating moiety.
作者信息
Papageorgiou A, Boutis L, Nicolaropoulos S, Catsoulacos P
出版信息
Oncology. 1987;44(2):128-32. doi: 10.1159/000226460.
PMID:3574853
Abstract
17 beta-Acetamido-5-androsten-3 beta-ol-p-bis(2-chloroethyl) aminophenylacetate and 17 beta-acetamido-5 alpha-androstan-3 beta-ol-p-bis(2-chloroethyl)aminophenylacetate, amido steroidal alkylating agents, were investigated in L1210 and P388 leukemias, Ehrlich ascites tumor, and adenocarcinoma CA-755. Both substances were determined to increase the life span of the tumor-bearing animals and to cause several long-term survivors in adenocarcinoma CA-755.
摘要
17β-乙酰氨基-5-雄甾烯-3β-醇对双（2-氯乙基）氨基苯乙酸酯和17β-乙酰氨基-5α-雄甾烷-3β-醇对双（2-氯乙基）氨基苯乙酸酯，酰胺甾体烷基化剂，在L1210和P388白血病、艾氏腹水瘤和腺癌CA-755中进行了研究。两种物质均被确定可延长荷瘤动物的寿命，并在腺癌CA-755中产生了一些长期存活者。
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