致癌物和非致癌物经胎盘对小鼠肺丙酮酸激酶和乳酸脱氢酶活性以及乳酸脱氢酶同工酶谱的影响。

Transplacental effects of carcinogens and non-carcinogens on activities of pyruvate kinase and lactate dehydrogenase as well as isozymic pattern of LDH in mouse lung.

作者信息

Rády P, Arany I, Uzvölgyi E, Boján F, Kertai P

出版信息

Toxicology. 1982;24(3-4):251-7. doi: 10.1016/0300-483x(82)90007-5.

DOI:10.1016/0300-483x(82)90007-5

Abstract

The carcinogens, urethane (URTH), 3-methylcholanthrene (MCA) and dimethylnitrosamine (DMN) given to pregnant mice enhanced permanently the activities of pyruvate kinase (PK) and lactate dehydrogenase (LDH) in the lungs of offspring even well before the appearance of lung tumours. The noncarcinogenic analogues phenylurethane (PHUR) and pyrene (PYR), had no effect on PK or LDH activity. The non-carcinogenic pulmonary toxicant Paraquat (PAR) elicited only a temporary elevation in the activities of the enzymes tested. The H:M ratio of LDH sub-units in the lung tissue was permanently decreased by URTH administered transplacentally. PAR caused only a temporary decrease in the H:M ratio, while PHUR had no effect on the isozymic pattern of LDH.

摘要

给怀孕小鼠注射致癌物质氨基甲酸乙酯（URTH）、3-甲基胆蒽（MCA）和二甲基亚硝胺（DMN），即使在肺部肿瘤出现之前很久，也会永久性地增强后代肺部丙酮酸激酶（PK）和乳酸脱氢酶（LDH）的活性。非致癌类似物苯基氨基甲酸乙酯（PHUR）和芘（PYR）对PK或LDH活性没有影响。非致癌性肺毒物百草枯（PAR）仅引起所测试酶活性的暂时升高。经胎盘给予URTH会使肺组织中LDH亚基的H:M比值永久性降低。PAR仅使H:M比值暂时降低，而PHUR对LDH的同工酶模式没有影响。

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